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Guidelines

MIRAGE

ADAM metallopeptidase domain 10

Summary

Gene Symbol

ADAM10

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397345
PubChem: 397345

Annotation

Keyword

Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O77633	Kuzbanian protein homolog Mammalian disintegrin-metalloprotease

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IEA	30032202
Notch signaling pathway	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
Golgi membrane
plasma membrane	IEA	30032202
adherens junction
clathrin-coated vesicle
axon

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endopeptidase activity
metalloendopeptidase activity
SH3 domain binding
metal ion binding
metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

SH3 domain binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin and metalloproteinase domain-containing protein 10

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
membrane protein ectodomain proteolysis
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
ADAM10, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026