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Guidelines

MIRAGE

CD59 molecule

Summary

Gene Symbol

CD59

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397347
PubChem: 397347

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O62680	MAC-inhibitory protein Membrane attack complex inhibition factor Protectin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
negative regulation of activation of membrane attack complex	IEA	30032202
innate immune response

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of activation of membrane attack complex

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
side of membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
complement binding	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

complement binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CD59

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Ly-6 antigen/uPA receptor-like
Snake toxin-like superfamily

Ortholog

Displaying entries **1 - 10** of 52 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	966		HUMAN05303
Mus musculus	12509		MOUSE34269
Rattus norvegicus	25407		RATNO26254
Mus musculus	333883		MOUSE34262
Bos taurus	505574		BOVIN07387
Macaca mulatta	693402		MACMU10009
Macaca mulatta	693993		MACMU10009
Pan troglodytes	739046		PANTR02610
Oryctolagus cuniculus	100009459		RABIT01150
Pongo abelii	100173870		PONAB03227

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025