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NPC intracellular cholesterol transporter 1

Summary

Gene Symbol

NPC1

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397591
PubChem: 397591

Annotation

Keyword

Cholesterol metabolism
Disulfide bond
Endosome
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P56941	Niemann-Pick C1 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
protein glycosylation
lysosomal transport
cholesterol metabolic process
bile acid metabolic process
intestinal cholesterol absorption

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

bile acid metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

intracellular lipid transport

intracellular sterol transport [inference]

intracellular cholesterol transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

intracellular lipid transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

intracellular lipid transport

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

intracellular lipid transport

intracellular sterol transport [inference]

intracellular cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region
nuclear envelope
lysosome
lysosomal membrane
endoplasmic reticulum

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lipid transporter activity	IEA	22301074
cholesterol binding

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cholesterol binding
intestinal cholesterol absorption
lipid transport
sterol transport

Displaying **all 3** entries
InterPro
Niemann-Pick C1, N-terminal
Protein patched/dispatched
Sterol-sensing domain

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements