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amyloid beta precursor protein

Summary

Gene Symbol

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397663
PubChem: 397663

Annotation

Keyword

Amyloid
Apoptosis
Cell adhesion
Cell membrane
Cell projection
Coated pit
Coiled coil
Copper
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Endocytosis
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Iron
Isopeptide bond
Metal-binding
Notch signaling pathway
Nucleus
Phosphoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Sulfation
Transmembrane helix
Ubl conjugation
Zinc

Proteins

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UniProt	Protein Name
A0A4X1UDV2
P79307	ABPP Alzheimer disease amyloid A4 protein homolog Alzheimer disease amyloid protein Amyloid precursor protein Amyloid-beta (A4) precursor protein Amyloid-beta A4 protein
Q2XQ99
A0A480E073
A0A4X1UC79
A0A481B6Z4
A0A4X1UF49
A0A286ZTE6
A0A4X1UE02
A0A8D1XLW3

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of translation
intracellular copper ion homeostasis
endocytosis
apoptotic process
cell adhesion

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

Notch signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cell recognition [inference]

neuron recognition [inference]

axon choice point recognition [inference]

axon midline choice point recognition

cell death [inference]

programmed cell death [inference]

apoptotic process

cell growth [inference]

developmental cell growth [inference]

collateral sprouting [inference]

collateral sprouting in absence of injury

vesicle-mediated transport [inference]

endocytosis

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

dendrite development

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

reproductive behavior [inference]

mating behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

locomotory behavior

adult locomotory behavior

visual behavior [inference]

visual learning

reproductive behavior [inference]

mating behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

anatomical structure development [inference]

dendrite development

system development [inference]

central nervous system development

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

growth [inference]

cell growth [inference]

developmental cell growth [inference]

collateral sprouting [inference]

collateral sprouting in absence of injury

developmental growth [inference]

developmental cell growth [inference]

collateral sprouting [inference]

collateral sprouting in absence of injury

developmental growth involved in morphogenesis [inference]

collateral sprouting [inference]

collateral sprouting in absence of injury

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

inorganic ion homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

import into cell [inference]

endocytosis

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of translation

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of translation

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

Notch signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth

regulation of biological quality [inference]

regulation of synapse structure or activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

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GO Term	Evidence Code	PMID
extracellular region
nucleus
cytoplasm
early endosome	IEA	30032202
endoplasmic reticulum

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

membrane microdomain [inference]

membrane raft

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Golgi-associated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Golgi-associated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Golgi-associated vesicle

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GO Term	Evidence Code	PMID
DNA binding
serine-type endopeptidase inhibitor activity	IEA	22301074
signaling receptor binding	IEA	30032202
heparin binding	IEA	22301074
signaling receptor activator activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity

molecular function activator activity [inference]

signaling receptor activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amyloid beta precursor protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
central nervous system development
heparin binding
metal ion binding
serine-type endopeptidase inhibitor activity
transition metal ion binding

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InterPro
Amyloidogenic glycoprotein, E2 domain
Amyloidogenic glycoprotein, copper-binding domain conserved site
Amyloidogenic glycoprotein, copper-binding domain superfamily
Amyloidogenic glycoprotein, copper-binding
Amyloidogenic glycoprotein, extracellular
Amyloidogenic glycoprotein, heparin-binding domain superfamily
Amyloidogenic glycoprotein, heparin-binding
Amyloidogenic glycoprotein, intracellular domain, conserved site
Amyloidogenic glycoprotein
Beta-amyloid precursor protein C-terminal

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements