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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

presenilin 2 S homeolog

Summary

Gene Symbol

psen2.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

397713

PubChem

397713

Alliance of Genome Resources

Xenbase:XB-GENE-6252626

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Notch signaling pathway
Phosphoprotein
Protease
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O12977	Presenilin beta
A0A8J0VE80

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
proteolysis	IEA
membrane protein ectodomain proteolysis
calcium ion transport
Notch signaling pathway	IEA
Notch receptor processing

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
nucleus
mitochondrial inner membrane
lysosomal membrane
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cell surface

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

Z disc

cell junction [inference]

synapse [inference]

neuromuscular junction

site of polarized growth [inference]

growth cone

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	IEA
peptidase activity	IEA
aspartic endopeptidase activity, intramembrane cleaving	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

aspartic endopeptidase activity, intramembrane cleaving

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Presenilin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
Notch receptor processing
amyloid precursor protein catabolic process
amyloid-beta metabolic process
aspartic endopeptidase activity, intramembrane cleaving
aspartic-type endopeptidase activity
calcium ion transport
hydrolase activity
membrane protein ectodomain proteolysis
proteolysis

Displaying **all 3** entries
InterPro
Peptidase A22A, presenilin
Presenilin, C-terminal
Presenilin/signal peptide peptidase

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026