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low density lipoprotein receptor L homeolog

Summary

Gene Symbol

ldlr.L

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

397757

PubChem

397757

Alliance of Genome Resources

Xenbase:XB-GENE-6252601

Annotation

Keyword

Cell membrane
Cholesterol metabolism
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
LDL
Lipid transport
Lysosome
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99087

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid transport	IEA
endocytosis	IEA
cholesterol metabolic process	IEA
cholesterol homeostasis
receptor-mediated endocytosis involved in cholesterol transport

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

organic substance transport [inference]

lipid transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
lysosome	IEA
endosome	IEA
early endosome	IEA
late endosome	IEA
Golgi apparatus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
low-density lipoprotein particle receptor activity
calcium ion binding	IEA
lipoprotein particle binding

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

low-density lipoprotein particle receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Low-density lipoprotein receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	3949	Xenbase:XB-GENE-962372
Xenopus tropicalis	16835	Xenbase:XB-GENE-962372
Xenopus tropicalis	174116	Xenbase:XB-GENE-962372
Xenopus tropicalis	300438	Xenbase:XB-GENE-962372
Xenopus tropicalis	373644	Xenbase:XB-GENE-962372
Xenopus tropicalis	397757	Xenbase:XB-GENE-962372