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Guidelines

MIRAGE

DNA ligase 1

Summary

Gene Symbol

LIG1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3978

PubChem

3978

Alliance of Genome Resources

HGNC:6598

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell division
DNA recombination
DNA repair
DNA replication
Disease variant
Ligase
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P18858	DNA ligase I Polydeoxyribonucleotide synthase [ATP] 1
A0A8V8TQC4
B4DM52
F5GZ28
A0A8V8TPH8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cell division	IEA
DNA repair	TAS	8696349
mismatch repair	TAS
DNA recombination
base-excision repair, gap-filling	TAS

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

cell cycle process [inference]

mitotic cell cycle process [inference]

Okazaki fragment processing involved in mitotic DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

developmental process [inference]

anatomical structure morphogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IBA
intracellular membrane-bounded organelle	IDA
nucleoplasm	IDA TAS
mitochondrion

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA ligase (ATP) activity	IBA
DNA binding	IEA
ATP binding	IEA
metal ion binding	IEA
protein binding	IPI	19336415

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming phosphoric ester bonds [inference]

DNA ligase activity

DNA ligase (ATP) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA ligase activity

DNA ligase (ATP) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 55** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gadus morhua	115548243		GADMO58906
Sparus aurata	115572628		SPAAU36293
Balaenoptera musculus	118885821		BALMU16294
Panthera leo	122208316		PANLE29231
Ursus americanus	123776290		URSAM22380

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Last updated: February 17, 2025