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DNA ligase 3

Summary

Gene Symbol

LIG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3980

PubChem

3980

Alliance of Genome Resources

HGNC:6600

JoGo

LIG3

TogoVar

LIG3

Annotation

Keyword

3D-structure
ATP-binding
Alternative initiation
Alternative splicing
Cell division
DNA recombination
DNA repair
DNA replication
Disease variant
Ligase
Magnesium
Metal-binding
Mitochondrion
Nucleus
Phosphoprotein
Primary mitochondrial disease
Proteomics identification
Reference proteome
Transit peptide
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z6I3
P49916	DNA ligase III Polydeoxyribonucleotide synthase [ATP] 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	TAS
DNA ligation
lagging strand elongation	IBA
base-excision repair	IDA	19589734
base-excision repair	IMP	24674627

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA ligation involved in DNA repair [inference]

base-excision repair, DNA ligation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

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GO Term	Evidence Code	PMID
nucleus	IDA	10207110 24837021
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
mitochondrion	IDA	10207110 24674627 24837021

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA ligase III-XRCC1 complex

catalytic complex [inference]

DNA ligase III-XRCC1 complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
DNA ligase activity	TAS
DNA ligase activity	IDA	19589734 24674627 9809069
DNA ligase (ATP) activity	IDA	7565692
DNA ligase (ATP) activity	IMP	10207110

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming phosphoric ester bonds [inference]

DNA ligase activity

DNA ligase (ATP) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA ligase activity

DNA ligase (ATP) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA Ligase I

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
ATP binding
DNA biosynthetic process
DNA ligase (ATP) activity
DNA ligase activity
DNA ligation
DNA recombination
DNA repair
Okazaki fragment processing involved in mitotic DNA replication
ligase activity
nucleotide binding

Displaying **all 7** entries
InterPro
DNA ligase, ATP-dependent, C-terminal
DNA ligase, ATP-dependent, N-terminal domain superfamily
DNA ligase, ATP-dependent, N-terminal
DNA ligase, ATP-dependent, central
DNA ligase, ATP-dependent, conserved site
DNA ligase, ATP-dependent
Nucleic acid-binding, OB-fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070451	mitochondrial DNA depletion syndrome 20	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements