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Guidelines

MIRAGE

cerberus 1, DAN family BMP antagonist S homeolog

Summary

Gene Symbol

cer1.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

398060

PubChem

398060

Alliance of Genome Resources

Xenbase:XB-GENE-865019

Annotation

Keyword

Cleavage on pair of basic residues
Differentiation
Disulfide bond
Gastrulation
Glycoprotein
Neurogenesis
Reference proteome
Secreted
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
P70041	Xcer

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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Last »
GO Term	Evidence Code	PMID
regionalization	IEA
cell surface receptor signaling pathway	IGI	12952900
gastrulation	IEA
nervous system development	IMP	12952900
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization

dorsal/ventral pattern formation [inference]

determination of dorsal identity

axis specification [inference]

anterior/posterior axis specification

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure development [inference]

animal organ development

heart development

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

negative regulation of developmental process [inference]

negative regulation of mesoderm development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of mesoderm development

regulation of mesoderm development [inference]

negative regulation of mesoderm development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of activin receptor signaling pathway

negative regulation of nodal signaling pathway

extracellular negative regulation of signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	TAS
extracellular region	IDA	10067895
extracellular region	IEA
extracellular space	NAS	8757128

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15466485
Wnt-protein binding	IPI	10067895
BMP binding	IPI	12885561
nodal binding	IPI	10067895

GO Hierarchy

molecular function

binding [inference]

protein binding

Wnt-protein binding

cytokine binding [inference]

BMP binding

nodal binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cerberus

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
determination of heart left/right asymmetry
negative regulation of activin receptor signaling pathway
regionalization

Displaying **all 4** entries
InterPro
Cerberus
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9350	Xenbase:XB-GENE-484971
Xenopus tropicalis	12622	Xenbase:XB-GENE-484971
Xenopus tropicalis	394437	Xenbase:XB-GENE-484971
Xenopus tropicalis	398060	Xenbase:XB-GENE-484971

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025