lipase C, hepatic type

Summary
Gene Symbol
  • LIPC
Aliases
  • HL
  • HTGL
  • Triacylglycerol lipase
Organism
Homo sapiens (human)
NCBI Gene
3990
HGNC
6619
KEGG Gene ID
hsa:3990
PubChem
3990
Alliance of Genome Resources
Annotation
Keyword
  • Calcium
  • Direct protein sequencing
  • Disease variant
  • Glycoprotein
  • HDL
  • Heparin-binding
  • Hydrolase
  • Lipid degradation
  • Metal-binding
  • Reference proteome
  • Secreted
  • Signal
Proteins
Displaying all 2 entries
UniProt Protein Name
A6H8L5
  • Lipase member C
  • Lysophospholipase
  • Phospholipase A1
P11150
  • Lipase member C
  • Lysophospholipase
  • Phospholipase A1
Gene Ontology (GO)
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
lipase I
Functional Category
  • I: Lipid transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Displaying all 2 entries
Gene Ontology
lipase activity
lipid metabolic process
KEGG BRITE Database
Orthology
K22283
Name
hepatic triacylglycerol lipase [EC:3.1.1.3]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 17 in total
DO ID Disease Name Source
DOID:10652 Alzheimer's disease
DOID:1168 familial hyperlipidemia
DOID:11801 protein-energy malnutrition
DOID:1184 nephrotic syndrome
DOID:1312 focal segmental glomerulosclerosis
DOID:13809 familial combined hyperlipidemia
DOID:1459 hypothyroidism
DOID:2018 hyperinsulinism
DOID:2237 hepatitis
DOID:326 ischemia
The Human Phenotype Ontology
Displaying entries 1 - 10 of 12 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000007 Autosomal recessive inheritance
HP:0000855 Insulin resistance
HP:0001013 Eruptive xanthomas
HP:0001084 Corneal arcus
HP:0001681 Angina pectoris
HP:0002155 Hypertriglyceridemia
HP:0003124 Hypercholesterolemia
HP:0003584 Late onset
HP:0005181 Premature coronary artery atherosclerosis
Displaying all 3 entries
Disease ID Disease Name
ORPHA:140905
  • hyperlipidemia due to hepatic triglyceride lipase deficiency
OMIM:125853
  • type 2 diabetes mellitus
OMIM:614025
  • hyperlipidemia due to hepatic triglyceride lipase deficiency
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001696
Gene Name
lipase, hepatic

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024