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adrenoceptor alpha 2A

Summary

Gene Symbol

ADRA2A

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 399501
PubChem: 399501

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18871	Alpha-2A adrenoreceptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
negative regulation of calcium ion transmembrane transporter activity
regulation of vasoconstriction	IEA	22301074
positive regulation of MAPK cascade
regulation of smooth muscle contraction	IEA	22301074

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

multicellular organismal process [inference]

cell activation [inference]

platelet activation

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
epinephrine binding
alpha2-adrenergic receptor activity	IEA	22301074
protein heterodimerization activity
alpha-1B adrenergic receptor binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

alpha-1B adrenergic receptor binding

protein dimerization activity [inference]

protein heterodimerization activity

organic cyclic compound binding [inference]

catecholamine binding [inference]

epinephrine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

alpha-adrenergic receptor activity [inference]

alpha2-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2C adrenergic receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
adrenergic receptor signaling pathway
alpha2-adrenergic receptor activity
epinephrine binding

Displaying **all 3** entries
InterPro
Adrenoceptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	150		HUMAN02960
Mus musculus	11551		MOUSE26767
Rattus norvegicus	25083		RATNO21099
Danio rerio	266750		DANRE23346
Bos taurus	282135	9913_0:00489f	BOVIN21549
Pan troglodytes	466201		PANTR01553
Macaca mulatta	695684		MACMU45706
Monodelphis domestica	100027878		MONDO03875
Equus caballus	100147119		HORSE16559
Ovis aries	100170317	9940_0:00482f

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OrthoDB (Group)

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