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adrenoceptor alpha 2A

Summary

Gene Symbol

ADRA2A

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 399501
PubChem: 399501

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18871	Alpha-2A adrenoreceptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
positive regulation of potassium ion transport
platelet activation	IEA	22301074
negative regulation of calcium ion transport
adenylate cyclase-activating G protein-coupled receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

multicellular organismal process [inference]

cell activation [inference]

platelet activation

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transport

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
epinephrine binding
alpha2-adrenergic receptor activity	IEA	22301074
protein heterodimerization activity
alpha-1B adrenergic receptor binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

alpha-1B adrenergic receptor binding

protein dimerization activity [inference]

protein heterodimerization activity

organic cyclic compound binding [inference]

catecholamine binding [inference]

epinephrine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

alpha-adrenergic receptor activity [inference]

alpha2-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2C adrenergic receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
adrenergic receptor signaling pathway
alpha2-adrenergic receptor activity
epinephrine binding

Displaying **all 3** entries
InterPro
Adrenoceptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **51 - 60** of 75 in total

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Salmo trutta	115147380		SALTR39051
Salmo trutta	115178424		SALTR67956
Takifugu rubripes	115253333		TAKRU17393
Gadus morhua	115539958		GADMO42398

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