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frizzled 2

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40090

PubChem

40090

Alliance of Genome Resources

FB:FBgn0016797

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9VVX3
M9PFW3
B7Z072

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
segment polarity determination	IGI	10457026 10556068 12636921 16163385
salivary gland morphogenesis	IMP	17507403
midgut development	IGI	10457026
motor neuron axon guidance	IMP	17764943

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

non-canonical Wnt signaling pathway

Frizzled Nuclear Import pathway

canonical Wnt signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

cell junction organization [inference]

synapse organization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

cuticle pattern formation [inference]

chitin-based larval cuticle pattern formation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing margin morphogenesis

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development [inference]

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemocyte proliferation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis

regulation of hemocyte proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

non-canonical Wnt signaling pathway

Frizzled Nuclear Import pathway

canonical Wnt signaling pathway

regulation of cell population proliferation [inference]

regulation of hemocyte proliferation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	24046358
early endosome	IDA	16530179
late endosome	IDA	16530179
plasma membrane	IDA	15514021 16530179 8717036
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

Wnt-Frizzled-LRP5/6 complex

Wnt signalosome

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
G protein-coupled receptor activity
Wnt-protein binding	IDA	8717036
Wnt-protein binding	IBA
Wnt-protein binding	IPI	12205098 16291792 22285813

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

Wnt-protein binding

protein domain specific binding [inference]

PDZ domain binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Frizzled

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Wnt receptor activity
Wnt-protein binding
canonical Wnt signaling pathway
cell surface receptor signaling pathway
non-canonical Wnt signaling pathway

Displaying **all 5** entries
InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
early endosome	PMID:16530179
late endosome	PMID:16530179
Wnt signalosome	PMID:12711303
nucleus	PMID:24046358
membrane	FB:FBrf0231198
plasma membrane	PMID:15514021 PMID:16530179 PMID:8717036

Ortholog

Displaying entries **1 - 10** of 19 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	7855	Xenbase:XB-GENE-479707
Xenopus tropicalis	8325	Xenbase:XB-GENE-480800
Caenorhabditis elegans	8326	WB:WBGene00000478
Caenorhabditis elegans	11211	WB:WBGene00000478
Caenorhabditis elegans	14362	WB:WBGene00000478
Xenopus tropicalis	14367	Xenbase:XB-GENE-479707
Xenopus tropicalis	14370	Xenbase:XB-GENE-480800
Caenorhabditis elegans	14371	WB:WBGene00000478
Xenopus tropicalis	40090	Xenbase:XB-GENE-480800
Caenorhabditis elegans	57265	WB:WBGene00000478

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements