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absent, small, or homeotic discs 1

Summary

Gene Symbol

ash1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40133

PubChem

40133

Alliance of Genome Resources

FB:FBgn0005386

Annotation

Keyword

Activator
Chromatin regulator
Chromosome
Developmental protein
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repeat
S-adenosyl-L-methionine
Transcription regulation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VW15	Absent small and homeotic disks protein 1 Lysine N-methyltransferase 2H

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
embryonic development via the syncytial blastoderm	IMP	7982557
positive regulation of gene expression	IMP	29158494
regulation of DNA-templated transcription	IBA IMP	17519021
regulation of transcription, DNA-templated	IBA IMP	17519021
oogenesis	IMP	7982557

GO Hierarchy

biological process

metabolic process [inference]

methylation

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

transcription initiation-coupled chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

reproductive behavior [inference]

egg-laying behavior

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

embryonic development via the syncytial blastoderm

behavior [inference]

reproductive behavior [inference]

egg-laying behavior

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

embryonic development via the syncytial blastoderm

cell development [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

retrotransposon silencing [inference]

retrotransposon silencing by heterochromatin formation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular process [inference]

retrotransposon silencing [inference]

retrotransposon silencing by heterochromatin formation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
polytene chromosome	IDA	11094082
protein-containing complex	IPI	11094082
nucleoplasm	IBA
chromatin	IDA	23580551
histone methyltransferase complex	IPI	29158494

GO Hierarchy

cellular component

protein-containing complex

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

histone methyltransferase complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

polytene chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

polytene chromosome

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GO Term	Evidence Code	PMID
histone H3K4 trimethyltransferase activity
histone acetyltransferase binding	IPI	11094082
chromatin binding	IDA IEA	29158494
histone H3K4 methyltransferase activity	IBA IDA IMP	13679578
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H4K20 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H4K20 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

histone methyltransferase activity

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

histone H4 methyltransferase activity [inference]

histone H4K20 methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H4K20 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H4K20 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

histone methyltransferase activity

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

histone H4 methyltransferase activity [inference]

histone H4K20 methyltransferase activity

histone modifying activity [inference]

histone methyltransferase activity

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone H3K4 trimethyltransferase activity

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 dimethyltransferase activity

histone H4 methyltransferase activity [inference]

histone H4K20 methyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

histone acetyltransferase binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phd finger protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 4** entries
InterPro
Zinc finger, FYVE/PHD-type
Zinc finger, PHD-type, conserved site
Zinc finger, PHD-type
Zinc finger, RING/FYVE/PHD-type

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nucleus	PMID:26896675
polytene chromosome	PMID:11094082
chromatin	PMID:23580551

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060037	developmental disorder of mental health	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080231	autosomal dominant intellectual developmental disorder 52	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 44 in total

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Species	Gene ID	OrthoDB
Drosophila serrata	110189866	7274_0:003623
Drosophila obscura	111080073	7282_1:00241e
Drosophila hydei	111605065	7224_1:0001e7
Drosophila novamexicana	115771424	47314_0:0006bc
Drosophila mauritiana	117141954	7226_1:001613
Drosophila albomicans	117572333	7291_1:001abf
Drosophila guanche	117579118	7266_1:000d90
Drosophila innubila	117786639	198719_1:001fa0
Drosophila subobscura	117893139	7241_0:001ff2
Drosophila subpulchrella	119552936	1486046_0:0012cf

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Annotation

OrthoDB (Group)

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Acknowledgements