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lactoperoxidase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4025

PubChem

4025

Alliance of Genome Resources

HGNC:6678

Annotation

Keyword

Alternative splicing
Antimicrobial
Calcium
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Nitration
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P22079	Salivary peroxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
detection of chemical stimulus involved in sensory perception of bitter taste	IDA	24248522
response to oxidative stress	NAS	8964511
thiocyanate metabolic process	IEA
defense response to bacterium	IDA	12626341
defense response to bacterium	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

thiocyanate metabolic process

sulfur compound metabolic process [inference]

thiocyanate metabolic process

xenobiotic metabolic process [inference]

thiocyanate metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

thiocyanate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

thiocyanate metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

thiocyanate metabolic process

sulfur compound metabolic process [inference]

thiocyanate metabolic process

xenobiotic metabolic process [inference]

thiocyanate metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	24248522
extracellular space	IBA
cytoplasm	IEA
basolateral plasma membrane	IDA	19059195

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
heme binding	IEA
thiocyanate peroxidase activity	IDA	12626341
thiocyanate peroxidase activity	IBA
metal ion binding	IEA
lactoperoxidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	4025	ZFIN:ZDB-GENE-030131-9460
Danio rerio	4353	ZFIN:ZDB-GENE-030131-9460
Drosophila melanogaster	7837	FB:FBgn0011828
Danio rerio	8288	ZFIN:ZDB-GENE-030131-9460
Danio rerio	13861	ZFIN:ZDB-GENE-030131-9460
Danio rerio	17523	ZFIN:ZDB-GENE-030131-9460
Danio rerio	38326	ZFIN:ZDB-GENE-030131-9460
Drosophila melanogaster	69675	FB:FBgn0011828
Mus musculus	76113		MOUSE06505
Drosophila melanogaster	137902	FB:FBgn0011828

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Acknowledgements