GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Notch signaling pathway
Protease
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O02194	dPS
M9PG70
B7Z090
M9PFS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	15611340
calcium ion homeostasis	IBA
Notch receptor processing, ligand-dependent	IDA IGI	15611340 20421416
wing disc dorsal/ventral pattern formation	IMP	16307735
amyloid-beta formation	IBA IDA IMP	12110170 20421416

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory [inference]

short-term memory

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

wing disc dorsal/ventral pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

memory [inference]

short-term memory

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

copper ion transport [inference]

copper ion import

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
recycling endosome	IDA	20421416
membrane	IEA
late endosome	IDA	20421416
apical plasma membrane	IDA	11781576
endoplasmic reticulum membrane

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23609534
endopeptidase activity	IBA IDA IMP	15105831 15611340 20421416 28495961
aspartic endopeptidase activity, intramembrane cleaving	IDA IEA	11030342
protein homodimerization activity	IPI	11557046

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PRESENILIN

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
Notch receptor processing
amyloid precursor protein catabolic process
amyloid-beta metabolic process
aspartic endopeptidase activity, intramembrane cleaving
aspartic-type endopeptidase activity
calcium ion transport
hydrolase activity
membrane protein ectodomain proteolysis
proteolysis

Displaying **all 3** entries
InterPro
Peptidase A22A, presenilin
Presenilin, C-terminal
Presenilin/signal peptide peptidase

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
membrane	FB:FBrf0231198
apical plasma membrane	PMID:10662508 PMID:11781576
plasma membrane	PMID:10662508
late endosome	PMID:20421416
gamma-secretase complex	PMID:12660785
recycling endosome	PMID:20421416
basal plasma membrane	PMID:10662508

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0060894	early-onset Parkinson's disease	Alliance of Genome Resources
DOID:0110040	Alzheimer's disease 4	Alliance of Genome Resources
DOID:0110042	Alzheimer's disease 3	Alliance of Genome Resources
DOID:0110427	dilated cardiomyopathy 1V	Alliance of Genome Resources
DOID:0110455	dilated cardiomyopathy 1U	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11870	Pick's disease	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:2280	hidradenitis suppurativa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	5663	HGNC:9508
Homo sapiens	5664	HGNC:9509
Mus musculus	19164	MGI:1202717
Mus musculus	19165	MGI:109284
Rattus norvegicus	29192	RGD:3425
Danio rerio	30221	ZFIN:ZDB-GENE-991119-4
Danio rerio	58026	ZFIN:ZDB-GENE-000330-9
Rattus norvegicus	81751	RGD:621060
Caenorhabditis elegans	180441	WB:WBGene00004769
Xenopus tropicalis	394924	Xenbase:XB-GENE-481916

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements