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cathepsin S

Summary

Gene Symbol

CTSS

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 403400
PubChem: 403400

Annotation

Keyword

Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8C0MLX9
Q8HY81

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
immune response	IEA	30032202
antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis involved in protein catabolic process	IEA	30032202
positive regulation of apoptotic signaling pathway

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
lysosome	IEA	30032202
phagocytic vesicle

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IEA	30032202
cysteine-type endopeptidase activator activity involved in apoptotic process

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

peptidase regulator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin S

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
hydrolase activity
immune response
positive regulation of apoptotic signaling pathway
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1520	HUMAN51935
Mus musculus	13040	MOUSE37136
Rattus norvegicus	50654	RATNO22866
Bos taurus	327711	BOVIN26025
Danio rerio	337572	DANRE11440
Pan troglodytes	457277	PANTR22186
Danio rerio	554157	DANRE11420
Macaca mulatta	708080	MACMU25714
Ovis aries	780472	SHEEP00791
Monodelphis domestica	100017406	MONDO12854