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Guidelines

MIRAGE

glutamate-ammonia ligase

Summary

Gene Symbol

GLUL

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 403443
KEGG Gene ID: cfa:403443
PubChem: 403443

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Angiogenesis
Cell membrane
Cytoplasm
Ligase
Magnesium
Manganese
Metal-binding
Microsome
Mitochondrion
Palmitate
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8C0PT10
Q8HZM5	Glutamate--ammonia ligase Palmitoyltransferase GLUL
A0A8I3MWJ7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
glutamine biosynthetic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process [inference]

glutamine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamine biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying 1 entry
GO Term	Evidence Code	PMID
glutamine synthetase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-ammonia (or amide) ligase activity [inference]

ammonia ligase activity [inference]

glutamine synthetase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutamine synthetase

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
catalytic activity
glutamine biosynthetic process
glutamine synthetase activity
ligase activity
nucleotide binding

Displaying **all 6** entries
InterPro
Glutamine synthetase, N-terminal conserved site
Glutamine synthetase, N-terminal domain superfamily
Glutamine synthetase, N-terminal domain
Glutamine synthetase, catalytic domain
Glutamine synthetase, glycine-rich site
Glutamine synthetase/guanido kinase, catalytic domain

KEGG BRITE Database

Orthology

K01915

Name

glutamine synthetase [EC:6.3.1.2]

References

Rhea

NH₄⁺ + L-glutamate + ATP

H⁺ + phosphate + ADP + L-glutamine

Enzyme

6.3.1.2

PMID

hexadecanoyl-CoA

CoA

Enzyme

2.3.1.225

PMID

Ortholog

Displaying entries **101 - 103** of **103** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Jaculus jaculus	123458615		JACJA20862
Jaculus jaculus	123463438		JACJA15268
Ursus americanus	123801396		URSAM26190

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025