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Guidelines

MIRAGE

dual oxidase 1

Summary

Gene Symbol

DUOX1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 403720
PubChem: 403720

Annotation

Keyword

Calcium
Cell membrane
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9MZF4	NADPH thyroid oxidase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
thyroid hormone generation
defense response	IEA	30032202
response to oxidative stress	IEA	22301074
cytokine-mediated signaling pathway
cuticle development

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

developmental process [inference]

anatomical structure development [inference]

cuticle development

response to stimulus [inference]

response to stress [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum
plasma membrane	IEA	30032202
apical plasma membrane
NADPH oxidase complex	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
peroxidase activity	IEA	22301074
calcium ion binding	IEA	22301074
NAD(P)H oxidase H2O2-forming activity
superoxide-generating NAD(P)H oxidase activity	IEA	30032202
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

superoxide-generating NAD(P)H oxidase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
Dual oxidase, peroxidase domain
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	53905		HUMAN22856
Mus musculus	99439		MOUSE32894
Rattus norvegicus	266807		RATNO26756
Pan troglodytes	467673		PANTR10218
Bos taurus	510409		BOVIN01422
Danio rerio	565097		DANRE28092
Macaca mulatta	713126		MACMU40736
Monodelphis domestica	100012836		MONDO05284
Equus caballus	100070541		HORSE16742
Taeniopygia guttata	100218721		TAEGU02071

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025