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adenosine A2a receptor

Summary

Gene Symbol

ADORA2A

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 403960
PubChem: 403960

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P11617

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
response to purine-containing compound
negative regulation of alpha-beta T cell activation
apoptotic signaling pathway
inhibitory postsynaptic potential
negative regulation of inflammatory response

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

apoptotic signaling pathway

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

feeding behavior [inference]

eating behavior

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound

response to amine [inference]

response to amphetamine

response to organic cyclic compound [inference]

response to purine-containing compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound

response to amine [inference]

response to amphetamine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation [inference]

negative regulation of alpha-beta T cell activation

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

inhibitory postsynaptic potential

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
postsynapse
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

postsynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
calmodulin binding
G protein-coupled adenosine receptor activity	IEA	22301074 30032202
enzyme binding
identical protein binding
lipid binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

lipid binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled adenosine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Adenosine receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of **120** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	135	HUMAN59609
Mus musculus	11540	MOUSE02270
Rattus norvegicus	25369	RATNO22361
Pan troglodytes	458714	PANTR26183
Sus scrofa	503661	PIGXX07298
Danio rerio	561701	DANRE43524
Bos taurus	617828	BOVIN09973
Macaca mulatta	707641	MACMU02824
Macaca mulatta	707865	MACMU02824
Monodelphis domestica	100029653	MONDO01029

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements