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ARF like GTPase 3

Summary

Gene Symbol

ARL3

Organism

Homo sapiens (human)

External Links

NCBI Gene

403

PubChem

403

Alliance of Genome Resources

HGNC:694

Annotation

Keyword

Cell division
Cell projection
Cytoskeleton
Direct protein sequencing
Disease variant
GTP-binding
Golgi apparatus
Joubert syndrome
Magnesium
Membrane
Metal-binding
Myristate
Nucleus
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P36405

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
small GTPase mediated signal transduction	IDA	22085962
protein transport	IEA
intraciliary transport	IEA
photoreceptor cell development	ISS
cilium assembly	IMP	22085962

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

intraciliary transport

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to ciliary membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to ciliary membrane

establishment of protein localization [inference]

protein transport

protein localization to membrane [inference]

protein localization to ciliary membrane

protein localization to cell periphery [inference]

protein localization to ciliary membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development

animal organ development [inference]

kidney development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development

localization [inference]

protein-containing complex localization [inference]

intraciliary transport

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to ciliary membrane

establishment of protein localization [inference]

protein transport

protein localization to membrane [inference]

protein localization to ciliary membrane

protein localization to cell periphery [inference]

protein localization to ciliary membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

microtubule-based transport [inference]

transport along microtubule [inference]

intraciliary transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to ciliary membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to ciliary membrane

establishment of protein localization [inference]

protein transport

protein localization to membrane [inference]

protein localization to ciliary membrane

protein localization to cell periphery [inference]

protein localization to ciliary membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
nucleus	IDA	16525022
nucleoplasm	IDA
cytoplasm	IBA
Golgi apparatus	IDA	16525022

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

midbody

ciliary transition zone [inference]

photoreceptor connecting cilium

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
GTPase activity	IEA
protein binding	IPI	11847227 16169070 18588884 22085962 26455799 27173435 28514442 30257685 32296183 33961781 35271311
GTP binding	IDA	18588884 22085962
GTP binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ADP-Ribosylation factor

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase superfamily, ARF/SAR type

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050777	Joubert syndrome	Alliance of Genome Resources
DOID:0112140	retinitis pigmentosa 83	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	403	Xenbase:XB-GENE-956688
Mus musculus	56350	Xenbase:XB-GENE-956688	MOUSE26560
Rattus norvegicus	64664		RATNO18962
Bos taurus	540040		BOVIN21434
Danio rerio	550525		DANRE04920
Sus scrofa	595114		PIGXX08412
Danio rerio	797451		DANRE03470
Equus caballus	100059896		HORSE16978
Ornithorhynchus anatinus	100080808		ORNAN08118
Pongo abelii	100172124		PONAB02259