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dual oxidase maturation factor 2

Summary

Gene Symbol

DUOXA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

405753

PubChem

405753

Alliance of Genome Resources

HGNC:32698

Annotation

Keyword

Alternative splicing
Congenital hypothyroidism
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q1HG44	Dual oxidase activator 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of cell motility	IDA	19339556
protein transport	IEA
regulation of thyroid hormone generation	IEA
hydrogen peroxide metabolic process	IEA
protein maturation	IGI	16651268

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

hydrogen peroxide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of thyroid hormone generation

regulation of hormone metabolic process [inference]

regulation of thyroid hormone generation

regulation of nitrogen compound metabolic process [inference]

regulation of thyroid hormone generation

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cell motility

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of thyroid hormone generation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

regulation of thyroid hormone generation

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
apical part of cell	IDA	25761904
cytosol	IDA	19339556

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

apical part of cell

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25761904
enzyme binding	IPI	19339556

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase maturation factor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Dual oxidase maturation factor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112184	thyroid dyshormonogenesis 5	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	34872		FB:FBgn0086711
Mus musculus	66811		MGI:1914061	MOUSE32877
Caenorhabditis elegans	182313		WB:WBGene00015519
Rattus norvegicus	499879		RGD:1560628	RATNO27583
Bos taurus	514414			BOVIN01424
Macaca mulatta	712992			MACMU40713
Pan troglodytes	743164	9598_0:003d9c		PANTR10214
Xenopus tropicalis	780018		Xenbase:XB-GENE-990812
Equus caballus	100070557			HORSE16752
Ornithorhynchus anatinus	100089165			ORNAN26549