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tumor associated calcium signal transducer 2

Summary

Gene Symbol

TACSTD2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4070

PubChem

4070

Alliance of Genome Resources

HGNC:11530

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Corneal dystrophy
Disulfide bond
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Tumor antigen
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
P09758	Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
visual perception	IEA
negative regulation of epithelial cell migration	ISS
regulation of epithelial cell proliferation	IEA
negative regulation of stress fiber assembly	ISS
ureteric bud morphogenesis	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

nephron epithelium morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of developmental process [inference]

negative regulation of morphogenesis of an epithelium [inference]

negative regulation of branching involved in ureteric bud morphogenesis

negative regulation of multicellular organismal process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

negative regulation of branching involved in ureteric bud morphogenesis

regulation of morphogenesis of an epithelium [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

negative regulation of branching involved in ureteric bud morphogenesis

negative regulation of morphogenesis of an epithelium [inference]

negative regulation of branching involved in ureteric bud morphogenesis

regulation of animal organ morphogenesis [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

negative regulation of branching involved in ureteric bud morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of morphogenesis of an epithelium [inference]

negative regulation of branching involved in ureteric bud morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

regulation of kidney development [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

negative regulation of branching involved in ureteric bud morphogenesis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

regulation of ruffle assembly [inference]

negative regulation of ruffle assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

regulation of ruffle assembly [inference]

negative regulation of ruffle assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

regulation of ruffle assembly [inference]

negative regulation of ruffle assembly

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of ruffle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of cell motility

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of multicellular organismal process [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

negative regulation of branching involved in ureteric bud morphogenesis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
nucleus	IBA
cytosol	TAS	10192395
basal plasma membrane	ISS
membrane	TAS	8382772

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane region [inference]

basal plasma membrane

lateral plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	15607035 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Epithelial cell adhesion molecule

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
EPCAM/Trop-2, C-terminal
Epithelial cell adhesion molecule N-terminal domain
Thyroglobulin type-1 superfamily
Thyroglobulin type-1
Transmembrane glycoprotein EPCAM/Trop-2

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060449	gelatinous drop-like corneal dystrophy	Alliance of Genome Resources
DOID:2566	corneal dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4070	Xenbase:XB-GENE-986667
Xenopus tropicalis	4072	Xenbase:XB-GENE-986667
Xenopus tropicalis	17075	Xenbase:XB-GENE-986667
Mus musculus	56753	Xenbase:XB-GENE-986667	MOUSE47380
Xenopus tropicalis	171577	Xenbase:XB-GENE-986667
Danio rerio	406454		DANRE05915
Pan troglodytes	456890		PANTR21223
Rattus norvegicus	494343	Xenbase:XB-GENE-986667	RATNO30347
Bos taurus	539853		BOVIN26852
Macaca mulatta	716294		MACMU23964

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements