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apolipoprotein C3

Summary

Gene Symbol

APOC3

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 408009
PubChem: 408009

Annotation

Keyword

Chylomicron
Direct protein sequencing
Lipid degradation
Lipid transport
Oxidation
Reference proteome
Secreted
Sialic acid
Signal
VLDL

Proteins

Displaying 1 entry
UniProt	Protein Name
P19035	Apolipoprotein C3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA	22301074 30032202
negative regulation of triglyceride catabolic process	IEA	30032202
negative regulation of very-low-density lipoprotein particle clearance	IEA	30032202
negative regulation of high-density lipoprotein particle clearance	IEA	30032202
negative regulation of low-density lipoprotein particle clearance	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

protein metabolic process [inference]

lipoprotein metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organic substance catabolic process [inference]

lipid catabolic process

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

regulation of high-density lipoprotein particle clearance [inference]

negative regulation of high-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

negative regulation of lipoprotein lipase activity

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
very-low-density lipoprotein particle	IEA	30032202
intermediate-density lipoprotein particle	IEA	30032202
spherical high-density lipoprotein particle	IEA	30032202
chylomicron	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle [inference]

spherical high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

cellular anatomical entity [inference]

extracellular region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phospholipid binding	IEA	30032202
lipase inhibitor activity	IEA	30032202
high-density lipoprotein particle receptor binding	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

high-density lipoprotein particle receptor binding

lipid binding [inference]

phospholipid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apolipoprotein C-III

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
high-density lipoprotein particle receptor binding
lipase inhibitor activity
lipid binding
lipid metabolic process
lipid transport
lipoprotein metabolic process
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle clearance

Displaying **all 2** entries
InterPro
Apolipoprotein CIII superfamily
Apolipoprotein CIII

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	345	HUMAN09530
Mus musculus	11814	MOUSE63358
Sus scrofa	406187	PIGXX35461
Canis lupus familiaris	442970	CANLF15257
Cavia porcellus	100135481	CAVPO10135
Callithrix jacchus	100413593	CALJA02903
Ailuropoda melanoleuca	100477899	AILME12515
Nomascus leucogenys	100599045	NOMLE10282
Cricetulus griseus	100774705	CRIGR21439
Otolemur garnettii	100956714	OTOGA07913