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arylsulfatase B

Summary

Gene Symbol

ARSB

Aliases

Organism

Homo sapiens (human)

External Links

NCBI Gene

411

HGNC

714

KEGG Gene ID

hsa:411

PubChem

411

Alliance of Genome Resources

HGNC:714

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Ichthyosis
Lysosome
Metachromatic leukodystrophy
Metal-binding
Mucopolysaccharidosis
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K4A0
P15848	N-acetylgalactosamine-4-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of epithelial cell migration	IMP	19306108
response to nutrient	IEA
lysosomal transport		2303452
lysosome organization		1718978
positive regulation of neuron projection development	ISS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

intestinal epithelial cell migration [inference]

colon epithelial cell migration

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to pH

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to methylmercury

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen
extracellular region
cell surface	ISS
lysosomal lumen
ficolin-1-rich granule lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
N-acetylgalactosamine-4-sulfatase activity	IDA	19306108
metal ion binding	IEA
arylsulfatase activity		2303452

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000113273

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **21 - 30** of 68 in total

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DO ID	Disease Name	Source
DOID:11328	schizophreniform disorder	DisGeNET
DOID:11984	hypertrophic cardiomyopathy	DisGeNET
DOID:12798	mucopolysaccharidosis	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:12799	mucopolysaccharidosis II	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:12800	mucopolysaccharidosis VI	Glyco-Disease Genes Database Glyco-Disease Genes Database Glyco-Disease Genes Database Glyco-Disease Genes Database DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET Alliance of Genome Resources
DOID:12801	mucopolysaccharidosis III	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:12802	mucopolysaccharidosis I	DisGeNET DisGeNET
DOID:12804	mucopolysaccharidosis IV	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:12932	endomyocardial fibrosis	DisGeNET
DOID:14159	obstructive hydrocephalus	DisGeNET

The Human Phenotype Ontology

Displaying entries **41 - 50** of 63 in total

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HPO ID	HPO Term
HP:0002938	Lumbar hyperlordosis
HP:0003016	Metaphyseal widening
HP:0003025	Metaphyseal irregularity
HP:0003274	Hypoplastic acetabulae
HP:0003300	Ovoid vertebral bodies
HP:0003311	Hypoplasia of the odontoid process
HP:0003521	Disproportionate short-trunk short stature
HP:0003593	Infantile onset
HP:0004322	Short stature
HP:0005180	Tricuspid regurgitation

Displaying 1 entry
Disease ID	Disease Name
OMIM:253200	mucopolysaccharidosis type 6

PubChem Disease

GHR Health Conditions

Mucopolysaccharidosis type VI

MedGen Diseases

Mucopolysaccharidosis type 6

OMIM Phenotypes

MUCOPOLYSACCHARIDOSIS, TYPE VI; MPS6

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	183778	WB:WBGene00006310
Drosophila melanogaster	39991	FB:FBgn0036765
Drosophila melanogaster	39994	FB:FBgn0036768
Drosophila melanogaster	317903	FB:FBgn0052191
Ciona intestinalis	100187202		CIOIN13273
Callorhinchus milii	103177857		CALMI13773
Latimeria chalumnae	102353782		LATCH15956
Lepisosteus oculatus	102689449		LEPOC06950
Danio rerio	110438237	ZFIN:ZDB-GENE-111123-2
Ictalurus punctatus	108279373		ICTPU11819

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PubChem Disease

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Acknowledgements