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arylsulfatase B

Summary

Gene Symbol

ARSB

Aliases

ASB

Organism

Homo sapiens (human)

External Links

NCBI Gene

411

HGNC

714

KEGG Gene ID

hsa:411

PubChem

411

Alliance of Genome Resources

HGNC:714

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Ichthyosis
Lysosome
Metachromatic leukodystrophy
Metal-binding
Mucopolysaccharidosis
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K4A0
P15848	N-acetylgalactosamine-4-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to estrogen	IEA
autophagy	IEA
response to methylmercury	IEA
colon epithelial cell migration	IMP	19306108
response to pH	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

intestinal epithelial cell migration [inference]

colon epithelial cell migration

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to pH

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to methylmercury

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen
extracellular region
cell surface	ISS
lysosomal lumen
ficolin-1-rich granule lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
N-acetylgalactosamine-4-sulfatase activity	IDA	19306108
metal ion binding	IEA
arylsulfatase activity		2303452

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000113273

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **61 - 68** of 68 in total

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DO ID	Disease Name	Source
DOID:6000	congestive heart failure	DisGeNET DisGeNET
DOID:820	myocarditis	DisGeNET
DOID:863	nervous system disease	DisGeNET
DOID:8923	skin melanoma	DisGeNET
DOID:8986	narcolepsy	DisGeNET
DOID:9256	colorectal cancer	DisGeNET
DOID:9455	lipid storage disease	DisGeNET
DOID:9521	Laron syndrome	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000158	Macroglossia
HP:0000238	Hydrocephalus
HP:0000256	Macrocephaly
HP:0000268	Dolichocephaly
HP:0000280	Coarse facial features
HP:0000365	Hearing impairment
HP:0000501	Glaucoma
HP:0000670	Carious teeth

Displaying 1 entry
Disease ID	Disease Name
OMIM:253200	mucopolysaccharidosis type 6

PubChem Disease

GHR Health Conditions

Mucopolysaccharidosis type VI

MedGen Diseases

Mucopolysaccharidosis type 6

OMIM Phenotypes

MUCOPOLYSACCHARIDOSIS, TYPE VI; MPS6

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Corvus moneduloides	116438058		CORMO27839
Strigops habroptila	115600825		STRHB08426

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024