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mannosidase alpha class 2C member 1

Summary

Gene Symbol

MAN2C1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4123

HGNC

6827

KEGG Gene ID

hsa:4123

PubChem

4123

Alliance of Genome Resources

HGNC:6827

JoGo

MAN2C1

TogoVar

MAN2C1

Annotation

Keyword

Alternative splicing
Cobalt
Cytoplasm
Glycosidase
Metal-binding
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJN9	Alpha-D-mannoside mannohydrolase Mannosidase alpha class 2C member 1
Q9NTJ4	Alpha mannosidase 6A8B Alpha-D-mannoside mannohydrolase Mannosidase alpha class 2C member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mannose metabolic process	IEA
oligosaccharide catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-mannosidase activity	IBA
carbohydrate binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha mannosidase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
mannose metabolic process
metal ion binding

Displaying **all 9** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal
Glycosyl hydrolases family 38, C-terminal beta sandwich domain

KEGG BRITE Database

Orthology

K01191

Name

alpha-mannosidase [EC:3.2.1.24]

References

16904268

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060990	congenital disorder of deglycosylation 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 33 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000158	Macroglossia
HP:0000218	High palate
HP:0000256	Macrocephaly
HP:0000316	Hypertelorism
HP:0000324	Facial asymmetry
HP:0000347	Micrognathia
HP:0000348	High forehead
HP:0000365	Hearing impairment
HP:0000480	Retinal coloboma