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microtubule affinity regulating kinase 3

Summary

Gene Symbol

MARK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4140

PubChem

4140

Alliance of Genome Resources

HGNC:6897

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A7I2V3B9
A0A7I2V2E3
Q86U11
H0YNV4
A0A7I2YQF7
P27448	C-TAK1 Cdc25C-associated protein kinase 1 ELKL motif kinase 2 Protein kinase STK10 Ser/Thr protein kinase PAR-1 Serine/threonine-protein kinase p78
A0A7I2V639

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
chromatin remodeling	IEA
protein phosphorylation	IMP	23666762
peptidyl-serine phosphorylation	IDA	9543386
positive regulation of protein binding	IDA	9543386

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	NAS	9543386
cytoplasm	IDA	23666762
cytoplasm	IBA
cytosol	TAS
plasma membrane	IDA	21145462

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	NAS	28386764
protein serine/threonine kinase activity	IDA	12941695 16822840 16980613 9543386
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tau protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
nucleotide binding

Displaying **all 3** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070356	visual impairment and progressive phthisis bulbi	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 73 in total

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Species	Gene ID	Orthologous MAtrix
Gorilla gorilla gorilla	101127838	GORGO08699
Octodon degus	101585417	OCTDE24239
Jaculus jaculus	101617054	JACJA17331
Mustela putorius furo	101690732	MUSPF12508
Anas platyrhynchos platyrhynchos	101793738	ANAPP18265
Melopsittacus undulatus	101869659	MELUD06881
Chrysemys picta bellii	101953187	CHRPI05090
Chinchilla lanigera	102009317	CHILA22840
Capra hircus	102172847	CAPHI14085
Latimeria chalumnae	102365343	LATCH08318

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OrthoDB (Group)

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Acknowledgements