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prolyl 3-hydroxylase 1

Summary

Gene Symbol

P3H1

Organism

Gallus gallus (chicken)

External Links

NCBI Gene: 414142
PubChem: 414142

Annotation

Keyword

Coiled coil
Dioxygenase
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6JHU8	Leucine- and proline-enriched proteoglycan 1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein stabilization
chaperone-mediated protein folding
collagen metabolic process	IEA	30032202
negative regulation of collagen fibril organization
negative regulation of post-translational protein modification

GO Hierarchy

biological process

metabolic process [inference]

collagen metabolic process

cellular process [inference]

protein folding [inference]

chaperone-mediated protein folding

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

bone development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of collagen fibril organization

negative regulation of extracellular matrix organization [inference]

negative regulation of collagen fibril organization

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of collagen fibril organization

negative regulation of extracellular matrix organization [inference]

negative regulation of collagen fibril organization

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of collagen fibril organization

negative regulation of extracellular matrix organization [inference]

negative regulation of collagen fibril organization

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of collagen fibril organization

regulation of collagen fibril organization [inference]

negative regulation of collagen fibril organization

regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of collagen fibril organization

regulation of collagen fibril organization [inference]

negative regulation of collagen fibril organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein-containing complex
endoplasmic reticulum	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
procollagen-proline 3-dioxygenase activity	IEA	30032202
iron ion binding	IEA	22301074
L-ascorbic acid binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Prolyl 3-hydroxylase 3

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-ascorbic acid binding
collagen metabolic process
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 3-dioxygenase activity

Displaying **all 5** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 3-hydroxylase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	OrthoDB
Meleagris gallopavo	100546471	9103_0:0034c2
Anas platyrhynchos	101793572	8839_0:003395
Anser cygnoides	106049155	8845_0:003a2c
Coturnix japonica	107323389	93934_0:00303b
Numida meleagris	110408525	8996_0:003025
Phasianus colchicus	116238345	9054_0:002dc7
Aythya fuligula	116497562	219594_0:002f76
Oxyura jamaicensis	118177153	8884_0:0031bb
Cygnus atratus	118258801	8868_0:002fac
Cygnus olor	121058273	8869_0:00311e