GlyCosmos Portal

Submissions

melanocortin 2 receptor

Summary

Gene Symbol

MC2R

Organism

Homo sapiens (human)

External Links

NCBI Gene

4158

PubChem

4158

Alliance of Genome Resources

HGNC:6930

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01718	Adrenocorticotropin receptor Melanocortin receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS	1325670
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9175632
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	19329486
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
neuropeptide signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IBA
melanocortin receptor activity	TAS	1325670
corticotropin receptor activity	IEA
protein binding	IPI	18077336 18840636 19151134 19329486 28298427

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

corticotropin receptor activity

neuropeptide receptor activity [inference]

corticotropin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

g_PROTEIN_RECEP_F1_2 domain-containing protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050562	West syndrome	Alliance of Genome Resources
DOID:0080621	glucocorticoid deficiency 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4158	Xenbase:XB-GENE-484146
Mus musculus	17200	Xenbase:XB-GENE-484146	MOUSE24007
Bos taurus	281299		BOVIN19691
Rattus norvegicus	282839		RATNO14187
Danio rerio	353152		DANRE10496
Ovis aries	443482		SHEEP11935
Takifugu rubripes	445998		TAKRU46212
Pan troglodytes	455500		PANTR15789
Felis catus	692350		FELCA28429
Monodelphis domestica	100018891		MONDO19360

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements