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melanocortin 3 receptor

Summary

Gene Symbol

MC3R

Organism

Homo sapiens (human)

External Links

NCBI Gene

4159

PubChem

4159

Alliance of Genome Resources

HGNC:6931

Annotation

Keyword

3D-structure
Biological rhythms
Cell membrane
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P41968

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8175743
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	19329486 19743876
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	8175743

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

multicellular organismal process [inference]

behavior [inference]

rhythmic behavior [inference]

circadian behavior [inference]

locomotor rhythm

locomotory behavior [inference]

locomotor rhythm

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

sodium ion homeostasis

inorganic ion homeostasis [inference]

sodium ion homeostasis

rhythmic process [inference]

circadian rhythm [inference]

circadian regulation of gene expression

circadian behavior [inference]

locomotor rhythm

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of behavior [inference]

regulation of feeding behavior

regulation of biological quality [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

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GO Term	Evidence Code	PMID
melanocortin receptor activity	TAS	8175743
melanocyte-stimulating hormone receptor activity	IBA
melanocyte-stimulating hormone receptor activity	IPI	19743876
protein binding	IPI	19329486 19743876
peptide hormone binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

melanocyte-stimulating hormone receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity

melanocyte-stimulating hormone receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

melanocortin 5 receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
melanocortin receptor activity
melanocyte-stimulating hormone receptor activity

Displaying **all 4** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Melanocortin receptor 3-5
Melanocortin/ACTH receptor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4159	Xenbase:XB-GENE-986713
Mus musculus	17201	Xenbase:XB-GENE-986713	MOUSE35002
Rattus norvegicus	29310	Xenbase:XB-GENE-986713	RATNO29202
Danio rerio	353153		DANRE42413
Bos taurus	505405		BOVIN04980
Macaca mulatta	698439		MACMU00494
Monodelphis domestica	100027970		MONDO05444
Equus caballus	100054477		HORSE20835
Ornithorhynchus anatinus	100078727		ORNAN26042
Sus scrofa	100141404		PIGXX11997

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements