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minichromosome maintenance complex component 3

Summary

Gene Symbol

MCM3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4172

PubChem

4172

Alliance of Genome Resources

HGNC:6945

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell cycle
Chromosome
DNA replication
DNA-binding
Direct protein sequencing
Glycoprotein
Helicase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 6** entries
UniProt	Protein Name
P25205	DNA polymerase alpha holoenzyme-associated protein P1 P1-MCM3 RLF subunit beta p102
J3KQ69
A0A0S2Z4T1
B4DUQ9
A0A0S2Z492
A0A499FHX9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
double-strand break repair via break-induced replication	IBA
DNA unwinding involved in DNA replication
DNA replication initiation	TAS	1549468
DNA strand elongation involved in DNA replication	IBA
regulation of DNA-templated DNA replication initiation	NAS	30069701

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding [inference]

DNA unwinding involved in DNA replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	HDA	19135898
nucleus	IDA	20531406 21383955 22474384
nucleus	IBA
nucleoplasm	TAS
alpha DNA polymerase:primase complex	TAS	1549468

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

DNA replication preinitiation complex [inference]

CMG complex

MCM complex

nuclear protein-containing complex [inference]

DNA replication preinitiation complex [inference]

CMG complex

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

perinuclear region of cytoplasm

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
DNA binding	TAS	1549468
single-stranded DNA binding	IBA
helicase activity
protein binding	IPI	12364596 15232106 16899510 17296731 19150984 19862764 22540012 24299456 25036637 26167883 26496610 28514442 29395061 31467278 33961781
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

single-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna replication licensing factor

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA unwinding involved in DNA replication
double-strand break repair via break-induced replication
hydrolase activity
metal ion binding
mitotic DNA replication initiation
nucleotide binding

Displaying **all 9** entries
InterPro
DNA replication licensing factor Mcm2
MCM OB domain
MCM domain
MCM, AAA-lid domain
MCM, N-terminal domain
Mini-chromosome maintenance protein
Mini-chromosome maintenance, conserved site
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase