GlyCosmos Portal

Submissions

minichromosome maintenance complex component 4

Summary

Gene Symbol

MCM4

Organism

Homo sapiens (human)

External Links

NCBI Gene

4173

PubChem

4173

Alliance of Genome Resources

HGNC:6947

Annotation

Keyword

3D-structure
Acetylation
Cell cycle
Chromosome
DNA replication
DNA-binding
Helicase
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P33991	CDC21 homolog P1-CDC21
B4DLA6
B3KMX0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
double-strand break repair via break-induced replication	IBA
DNA replication	NAS	9465298
DNA replication	IBA
DNA unwinding involved in DNA replication
DNA strand elongation involved in DNA replication	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding [inference]

DNA unwinding involved in DNA replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
chromosome, telomeric region	HDA	19135898
nucleus	NAS	8265339
nucleus	IDA	22474384
nucleus	IBA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

DNA replication preinitiation complex [inference]

CMG complex

MCM complex

nuclear protein-containing complex [inference]

DNA replication preinitiation complex [inference]

CMG complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
DNA helicase activity	IDA	25661590 9305914
single-stranded DNA binding	ISS
single-stranded DNA binding	IDA	25661590
protein binding	IPI	12364596 15232106 16902406 17296731 22190034 22540012 23764002 24299456 24407287 25036637 28514442 33961781 35271311
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA replication licensing factor

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
L: Replication, recombination and repair

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA strand elongation involved in DNA replication
DNA unwinding involved in DNA replication
double-strand break repair via break-induced replication
hydrolase activity
mitotic DNA replication initiation
nucleotide binding

Displaying **all 9** entries
InterPro
MCM OB domain
MCM domain
MCM, AAA-lid domain
MCM, N-terminal domain
Mini-chromosome maintenance complex protein 4
Mini-chromosome maintenance protein
Mini-chromosome maintenance, conserved site
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase