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angiotensin I converting enzyme 2

Summary

Gene Symbol

ACE2

Organism

Gallus gallus (chicken)

External Links

NCBI Gene: 418623
PubChem: 418623

Annotation

Keyword

Carboxypeptidase
Cell projection
Chloride
Cytoplasm
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A5J6CU64

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of gap junction assembly
proteolysis	IEA	22301074 30032202
regulation of cardiac conduction
tryptophan transport
positive regulation of L-proline import across plasma membrane

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

drinking behavior [inference]

angiotensin-mediated drinking behavior

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell [inference]

receptor-mediated virion attachment to host cell [inference]

entry receptor-mediated virion attachment to host cell

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

nitrogen compound transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac conduction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
apical plasma membrane
plasma membrane	IEA	30032202
cell surface
brush border membrane
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
peptidyl-dipeptidase activity	IEA	22301074 30032202
metal ion binding
identical protein binding
endopeptidase activity
metallopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

exopeptidase activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	OrthoDB
Meleagris gallopavo	100541186	9103_1:00017a
Anas platyrhynchos	101792697	8839_0:000167
Anser cygnoides	106037784	8845_0:00141f
Coturnix japonica	107325566	93934_0:0001c8
Numida meleagris	110392736	8996_0:0005cb
Phasianus colchicus	116230727	9054_0:00172e
Aythya fuligula	116498237	219594_0:000631
Oxyura jamaicensis	118167544	8884_0:0003cf
Cygnus atratus	118245768	8868_0:0003ae
Cygnus olor	121057951	8869_0:000221

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UniCarb-DR

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements