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ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

Summary

Gene Symbol

ART4

Aliases

ARTC4
CD297
DOK1
NAD(+)--protein-arginine ADP-ribosyltransferase 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

420

HGNC

726

KEGG Gene ID

hsa:420

PubChem

420

Alliance of Genome Resources

HGNC:726

Annotation

Keyword

Blood group antigen
Cell membrane
Disulfide bond
GPI-anchor
Glycosyltransferase
NAD
NADP
Nucleotidyltransferase
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q93070	ADP-ribosyltransferase C2 and C3 toxin-like 4 Dombrock blood group carrier molecule Mono(ADP-ribosyl)transferase 4 NAD(P)(+)--arginine ADP-ribosyltransferase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
arginine metabolic process	NAS	11001920

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

arginine metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
plasma membrane	TAS
side of membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

side of membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IBA
nucleotidyltransferase activity	IEA
NAD+-protein-arginine ADP-ribosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity [inference]

NAD+-protein-arginine ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity [inference]

NAD+-protein-arginine ADP-ribosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ADP ribosyltransferase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NAD+ ADP-ribosyltransferase activity
nucleotidyltransferase activity
transferase activity

Displaying 1 entry
InterPro
NAD

KEGG BRITE Database

Orthology

K06717

Name

ADP-ribosyltransferase 4 [EC:2.4.2.31]

References

Rhea

RHEA:19149

NAD⁺

H⁺ + nicotinamide

Enzyme

2.4.2.31

PMID

RHEA:54884

NADP⁺

H⁺ + nicotinamide

Enzyme

2.4.2.31

PMID

225315

Disease

PubChem Disease

MedGen Diseases

Blood group, Dombrock system

OMIM Phenotypes

BLOOD GROUP, DOMBROCK SYSTEM; DO

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	417	ZFIN:ZDB-GENE-070725-5
Danio rerio	420	ZFIN:ZDB-GENE-070725-5
Danio rerio	11870	ZFIN:ZDB-GENE-070725-5
Danio rerio	11871	ZFIN:ZDB-GENE-070725-5
Danio rerio	11875	ZFIN:ZDB-GENE-070725-5
Mus musculus	109978	ZFIN:ZDB-GENE-070725-5	MOUSE49857
Danio rerio	116969	ZFIN:ZDB-GENE-070725-5
Danio rerio	259167	ZFIN:ZDB-GENE-070725-5
Rattus norvegicus	312806		RATNO31840
Bos taurus	407146		BOVIN30178

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements