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meprin A subunit beta

Summary

Gene Symbol

MEP1B

Organism

Homo sapiens (human)

External Links

NCBI Gene

4225

PubChem

4225

Alliance of Genome Resources

HGNC:7020

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Inflammatory response
Metal-binding
Metalloprotease
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q16820	Endopeptidase-2 Meprin B N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta PABA peptide hydrolase PPH beta
J3QKX5	Endopeptidase-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
inflammatory response	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	9288916
extracellular region	IEA
meprin A complex	IDA	9288916

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

meprin A complex

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23123160 27180358 9288916
zinc ion binding	IEA
metalloendopeptidase activity	IBA
identical protein binding	IPI	22988105 27180358

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metalloendopeptidase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 3** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 77** of 77 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Gadus morhua	115555287		GADMO06779
Gadus morhua	115555288		GADMO06779
Sparus aurata	115590939		SPAAU67770
Rhinolophus ferrumequinum	117038642		RHIFE19885
Balaenoptera musculus	118880034		BALMU02636
Panthera leo	122203124		PANLE00006
Pongo pygmaeus	129018639	9600_0:004683

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements