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Autophagy-related 6

Summary

Gene Symbol

Atg6

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42850

PubChem

42850

Alliance of Genome Resources

FB:FBgn0264325

Annotation

Keyword

Coiled coil
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VCE1	Autophagy protein 6-like

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
autophagy	IEA IMP	23406899
late endosome to vacuole transport	IBA
endocytosis	IMP	23406899
mitophagy	IBA
neuron remodeling	IMP	25458013

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

cell death [inference]

programmed cell death [inference]

programmed cell death involved in cell development [inference]

larval midgut cell programmed cell death

vesicle-mediated transport [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

larval midgut cell programmed cell death

cell development [inference]

hemopoiesis

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

late endosome to vacuole transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to nitrogen starvation

process utilizing autophagic mechanism [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion [inference]

mitophagy

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

export from cell [inference]

secretion by cell [inference]

protein secretion

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

anatomical structure development [inference]

cell development [inference]

hemopoiesis

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

larval midgut cell programmed cell death

cell development [inference]

hemopoiesis

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to oxidative stress

cellular response to stress [inference]

cellular response to starvation

cellular response to nitrogen starvation

response to starvation [inference]

cellular response to starvation

cellular response to nitrogen starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

response to starvation [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to nitrogen starvation

cellular response to nitrogen levels [inference]

cellular response to nitrogen starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to nitrogen starvation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

vacuolar transport [inference]

late endosome to vacuole transport

organic substance transport [inference]

protein transport [inference]

protein secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

import into cell [inference]

endocytosis

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

late endosome to vacuole transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

late endosome to vacuole transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phagophore assembly site	IBA
phosphatidylinositol 3-kinase complex, class III, type II	IBA
phosphatidylinositol 3-kinase complex, class III, type I	IBA IDA	18474623

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III [inference]

cellular anatomical entity [inference]

phagophore assembly site

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase binding	IBA
small GTPase binding	IDA	32248620
protein-macromolecule adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

phosphatidylinositol 3-kinase binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beclin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
autophagosome assembly
cellular response to nitrogen starvation
late endosome to vacuole transport

Displaying **all 4** entries
InterPro
Atg6, BARA domain
Atg6/Beclin C-terminal domain superfamily
Atg6/Beclin
Atg6/beclin, coiled-coil domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
phosphatidylinositol 3-kinase complex, class III, type I	PMID:18474623

Disease

Disease Ontology

Displaying entries **1 - 10** of 39 in total

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DO ID	Disease Name	Source
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0080546	non-alcoholic fatty liver	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:0080998	acute necrotizing pancreatitis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12010	anterior ischemic optic neuropathy	Alliance of Genome Resources
DOID:1440	Machado-Joseph disease	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8678		HGNC:1034
Mus musculus	56208		MGI:1891828
Rattus norvegicus	114558		RGD:620190
Caenorhabditis elegans	177345		WB:WBGene00000247
Mus musculus	226720		MGI:2684950
Rattus norvegicus	289269		RGD:1563293
Danio rerio	393846		ZFIN:ZDB-GENE-040426-1666
Homo sapiens	441925		HGNC:38606
Xenopus tropicalis	619357		Xenbase:XB-GENE-999318
Saccharomyces cerevisiae S288C	855983		SGD:S000006041

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Last updated: December 9, 2024