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tolkin

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42944

PubChem

42944

Alliance of Genome Resources

FB:FBgn0004885

Annotation

Keyword

Cell projection
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Neurogenesis
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VC47	Tolloid-related protein Tolloid-related protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
proteolysis	IEA
axon guidance	IMP	17119021
defasciculation of motor neuron axon	IMP	16971470
motor neuron axon guidance	IMP	16971470
imaginal disc-derived wing vein morphogenesis	IMP	15872004

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cell recognition [inference]

neuron recognition [inference]

axonal defasciculation [inference]

defasciculation of motor neuron axon

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

motor neuron axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing vein morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	17119021
extracellular space	IBA
axon
perikaryon

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

perikaryon

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IDA	17119021
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
calcium ion binding	IEA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tolloid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 10** entries
InterPro
Bone morphogenetic protein 1/tolloid-like protein
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase
Spermadhesin, CUB domain superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:17119021

Ortholog

Displaying entries **1 - 10** of 11 in total

1

2

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	649	Xenbase:XB-GENE-479191
Xenopus tropicalis	7092	Xenbase:XB-GENE-479941
Xenopus tropicalis	7093	Xenbase:XB-GENE-478930
Xenopus tropicalis	12153	Xenbase:XB-GENE-479191
Xenopus tropicalis	24087	Xenbase:XB-GENE-478930
Xenopus tropicalis	42944	Xenbase:XB-GENE-479191
Xenopus tropicalis	42945	Xenbase:XB-GENE-479191
Xenopus tropicalis	183207	Xenbase:XB-GENE-478930
Xenopus tropicalis	185492	Xenbase:XB-GENE-478930
Xenopus tropicalis	399178	Xenbase:XB-GENE-479941