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tolloid

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42945

PubChem

42945

Alliance of Genome Resources

FB:FBgn0003719

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P25723

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	12925593 9363950
proteolysis	IEA
maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP	16781701
amnioserosa formation	IMP	11260716
imaginal disc-derived wing vein morphogenesis	IMP	15872004

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

axis specification [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

dorsal/ventral axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing vein morphogenesis

anatomical structure formation involved in morphogenesis [inference]

amnioserosa formation

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	9363950
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IDA	12925593 15797386 17119021 21839924 25642644 9363950 9827802
metalloendopeptidase activity	IMP	10769238
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
calcium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tolloid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 10** entries
InterPro
Bone morphogenetic protein 1/tolloid-like protein
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase
Spermadhesin, CUB domain superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:9363950

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	649	Xenbase:XB-GENE-479191
Xenopus tropicalis	7092	Xenbase:XB-GENE-479941
Xenopus tropicalis	7093	Xenbase:XB-GENE-478930
Xenopus tropicalis	12153	Xenbase:XB-GENE-479191
Xenopus tropicalis	24087	Xenbase:XB-GENE-478930
Xenopus tropicalis	42944	Xenbase:XB-GENE-479191
Xenopus tropicalis	42945	Xenbase:XB-GENE-479191
Xenopus tropicalis	183207	Xenbase:XB-GENE-478930
Xenopus tropicalis	185492	Xenbase:XB-GENE-478930
Xenopus tropicalis	399178	Xenbase:XB-GENE-479941