GlyCosmos Portal

Submissions

matrix metallopeptidase 13

Summary

Gene Symbol

MMP13

Organism

Homo sapiens (human)

External Links

NCBI Gene

4322

PubChem

4322

Alliance of Genome Resources

HGNC:7159

Annotation

Keyword

3D-structure
Calcium
Collagen degradation
Direct protein sequencing
Disease variant
Disulfide bond
Dwarfism
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P45452	Matrix metalloproteinase-13
Q53H33	Matrix metalloproteinase-13

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
endochondral ossification	IEA
growth plate cartilage development	IEA
proteolysis	IEA
extracellular matrix disassembly	TAS
extracellular matrix disassembly	IMP	8576151 9065415

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development [inference]

growth plate cartilage development

animal organ development [inference]

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis [inference]

growth plate cartilage development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
extracellular matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
endopeptidase activity	IDA	18164633
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA	8576151 9065415
metalloendopeptidase activity	IBA
serine-type endopeptidase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metallopeptidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
collagen catabolic process
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 8** entries
InterPro
Hemopexin-like repeats
Metallopeptidase, catalytic domain superfamily
PGBD-like superfamily
Peptidase M10, metallopeptidase
Peptidase M10A, catalytic domain
Peptidase M10A
Peptidase, metallopeptidase
Peptidoglycan binding-like

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0080030	spondyloepimetaphyseal dysplasia, Missouri type	Alliance of Genome Resources
DOID:13714	anodontia	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:4001	ovarian carcinoma	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **100** in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	4312	WB:WBGene00016283
Caenorhabditis elegans	4314	WB:WBGene00016283
Caenorhabditis elegans	4317	WB:WBGene00016283
Caenorhabditis elegans	4321	WB:WBGene00016283
Xenopus tropicalis	4322	Xenbase:XB-GENE-481559
Caenorhabditis elegans	4323	WB:WBGene00010423
Caenorhabditis elegans	4324	WB:WBGene00010423
Caenorhabditis elegans	4325	WB:WBGene00010423
Caenorhabditis elegans	4326	WB:WBGene00010423
Caenorhabditis elegans	4327	WB:WBGene00016283

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements