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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
matrix metallopeptidase 13
Summary
- Gene Symbol
-
- MMP13
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Collagen degradation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Dwarfism
- Extracellular matrix
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Zinc
- Zymogen
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| bone mineralization | ||
| endochondral ossification | ||
| response to amyloid-beta | ||
| extracellular matrix disassembly |
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular matrix | ||
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| zinc ion binding | ||
| metalloendopeptidase activity | ||
| endopeptidase activity | ||
| collagen binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- metallopeptidase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| collagen catabolic process |
| extracellular matrix organization |
| hydrolase activity |
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| zinc ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080030 | spondyloepimetaphyseal dysplasia, Missouri type | |
| DOID:0080176 | meningococcal meningitis | |
| DOID:10283 | prostate cancer | |
| DOID:10325 | silicosis | |
| DOID:10808 | gastric ulcer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:12236 | primary biliary cholangitis | |
| DOID:1245 | vulva cancer | |
| DOID:13714 | anodontia | |
| DOID:14018 | alcoholic liver cirrhosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 17386 | MGI:1340026 | MOUSE64508 | ||
| 171052 | RGD:620196 | RATNO40397 | ||
| 176025 | WB:WBGene00020646 | |||
| 178748 | WB:WBGene00016283 | |||
| 281914 | BOVIN06328 | |||
| 379564 | Xenbase:XB-GENE-6255468 | |||
| 387293 | ZFIN:ZDB-GENE-031202-2 | |||
| 397346 | PIGXX35284 | |||
| 403763 | CANLF15346 | |||
| 451513 | 9598_0:002e4c | PANTR04187 |
