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MIRAGE
matrix metallopeptidase 14
Summary
- Gene Symbol
-
- MMP14
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Cleavage on pair of basic residues
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Metal-binding
- Metalloprotease
- Osteoporosis
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P50281 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| skeletal system development | ||
| angiogenesis | ||
| ovarian follicle development | ||
| response to hypoxia | ||
| endothelial cell proliferation |
GO Hierarchy
biological process
metabolic process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| extracellular space | ||
| nucleus | ||
| cytoplasm | ||
| Golgi lumen |
| GO Term | Evidence Code | PMID |
|---|---|---|
| endopeptidase activity | ||
| metalloendopeptidase activity | ||
| metalloendopeptidase activity | ||
| metalloendopeptidase activity | ||
| metalloendopeptidase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- metallopeptidase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| collagen catabolic process |
| extracellular matrix organization |
| hydrolase activity |
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| zinc ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080696 | Winchester syndrome | |
| DOID:4914 | esophagus adenocarcinoma | |
| DOID:5844 | myocardial infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 4312 | WB:WBGene00010423 | ||
| 4314 | WB:WBGene00010423 | ||
| 4317 | WB:WBGene00010423 | ||
| 4321 | WB:WBGene00010423 | ||
| 4322 | WB:WBGene00010423 | ||
| 4323 | Xenbase:XB-GENE-485643 | ||
| 4324 | FB:FBgn0033438 | ||
| 4325 | FB:FBgn0033438 | ||
| 4326 | FB:FBgn0033438 | ||
| 4327 | WB:WBGene00010423 |
