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neuregulin 2

Summary

Gene Symbol

Nrg2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

432361

PubChem

432361

Alliance of Genome Resources

RGD:1303302

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Immunoglobulin domain
Reference proteome
Secreted
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35569

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
signal transduction	IEA
cell surface receptor signaling pathway	ISO
epidermal growth factor receptor signaling pathway	IDA	9348101
nervous system development	IEA
intracellular signal transduction	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

developmental process [inference]

anatomical structure development [inference]

animal organ development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of synapse maturation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	12466964
extracellular space	IBA
extracellular space	IEA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

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GO Term	Evidence Code	PMID
epidermal growth factor receptor activity	IDA	9348101
signaling receptor binding	IBA
epidermal growth factor receptor binding	IDA	9348101
growth factor activity	IEA
ErbB-3 class receptor binding	IDA	9348101

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

binding [inference]

protein binding [inference]

signaling receptor binding

ErbB-3 class receptor binding

receptor ligand activity

growth factor activity

growth factor receptor binding [inference]

epidermal growth factor receptor binding

ErbB-4 class receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

epidermal growth factor receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pro-neuregulin-2, membrane-bound isoform

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
animal organ development
growth factor activity
nervous system development
signaling receptor binding

Displaying **all 4** entries
InterPro
Immunoglobulin subtype 2
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3084	FB:FBgn0003984
Homo sapiens	9542	ZFIN:ZDB-GENE-070615-10	HUMAN81145
Danio rerio	38657	ZFIN:ZDB-GENE-090205-2
Danio rerio	432361	ZFIN:ZDB-GENE-090205-2
Canis lupus familiaris	487158		CANLF06621
Macaca mulatta	694995		MACMU39462
Bos taurus	783452		BOVIN33555
Danio rerio	100006951		DANRE20736
Mus musculus	100042150		MOUSE23713
Taeniopygia guttata	100219062		TAEGU04602