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MIRAGE

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

Summary

Gene Symbol

Gnptab

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

432486

PubChem

432486

Alliance of Genome Resources

MGI:3643902

Annotation

Keyword

Alternative splicing
Calcium
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Reference proteome
Repeat
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q69ZN6	GlcNAc-1-phosphotransferase subunits alpha/beta Stealth protein GNPTAB UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
lysosome organization	ISS
lysosome organization	ISO
protein secretion	IMP	17652091
N-glycan processing to lysosome	ISS
N-glycan processing to lysosome	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

export from cell [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

organic substance transport [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

export from cell [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	ISO
Golgi apparatus	ISS
Golgi apparatus	ISO
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	ISS
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	ISO
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	IBA
calcium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
N-glycan processing to lysosome
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
carbohydrate phosphorylation
transferase activity, transferring phosphorus-containing groups
transferase activity

Displaying **all 8** entries
InterPro
N-acetylglucosamine-1-phosphotransferase subunit alpha/beta, regulatory domain
Notch domain
Notch-like domain superfamily
Stealth family
Stealth protein CR1, conserved region 1
Stealth protein CR2, conserved region 2
Stealth protein CR3, conserved region 3
Stealth protein CR4, conserved region 4

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080070	mucolipidosis II alpha/beta	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	79158	ZFIN:ZDB-GENE-030131-4714	HUMAN14957
Rattus norvegicus	362865		RATNO38273
Danio rerio	432486	ZFIN:ZDB-GENE-030131-4714
Pan troglodytes	452176		PANTR06708
Canis lupus familiaris	475443		CANLF04280
Bos taurus	509610		BOVIN29819
Danio rerio	553365	ZFIN:ZDB-GENE-030131-4714	DANRE34703
Macaca mulatta	697307		MACMU03767
Monodelphis domestica	100021000		MONDO35512
Equus caballus	100067011		HORSE26100

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025