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N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

Summary

Gene Symbol

Gnptab

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

432486

PubChem

432486

Alliance of Genome Resources

MGI:3643902

Annotation

Keyword

Alternative splicing
Calcium
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Reference proteome
Repeat
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q69ZN6	GlcNAc-1-phosphotransferase subunits alpha/beta Stealth protein GNPTAB UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
establishment of localization in cell	IMP	17652091
N-glycan processing to lysosome	IBA ISO ISS
carbohydrate phosphorylation	IMP ISO	17652091
secretion of lysosomal enzymes	IMP	19710420
lysosome organization	ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing [inference]

N-glycan processing to lysosome

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

export from cell [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

organic substance transport [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

export from cell [inference]

secretion by cell [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

secretion of lysosomal enzymes

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA ISO ISS
Golgi membrane	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	IBA ISO ISS
calcium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Functional Category

I: Lipid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism

Displaying **all 6** entries
Gene Ontology
N-glycan processing to lysosome
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
calcium ion binding
carbohydrate phosphorylation
transferase activity, transferring phosphorus-containing groups
transferase activity

Displaying entry **11 - 11** of 11 in total

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InterPro
Stealth protein CR4, conserved region 4

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080070	mucolipidosis II alpha/beta	Alliance of Genome Resources
DOID:0080071	mucolipidosis III alpha/beta	Alliance of Genome Resources
DOID:0080488	mucolipidosis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cercocebus atys	105573316		CERAT12317
Aotus nancymaae	105728860		AOTNA01932
Propithecus coquereli	105815137		PROCO23960
Dipodomys ordii	105987699	10020_0:000388	DIPOR01485
Salmo salar	106609432		SALSA136593
Marmota marmota marmota	107139968	9994_0:000248
Ictalurus punctatus	108274741		ICTPU07014
Rhinopithecus bieti	108543135		RHIBE26565
Cyprinus carpio carpio	109052697		CYPCA32522
Cyprinus carpio carpio	109071546		CYPCA62168

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements