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myosin IA

Summary

Gene Symbol

Myo1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

432516

PubChem

432516

Alliance of Genome Resources

MGI:107732

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Myosin
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
O88329	Brush border myosin I Myosin I heavy chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IBA ISO ISS
endocytosis	IBA
vesicle localization	ISO ISS
microvillus assembly	IMP	15758024
regulation of protein localization	ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin filament-based movement

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

cell projection organization

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

plasma membrane bounded cell projection organization [inference]

microvillus organization [inference]

microvillus assembly

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

organelle localization [inference]

vesicle localization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of protein localization

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GO Term	Evidence Code	PMID
plasma membrane raft	IDA	20089841
myosin complex	IEA
lateral plasma membrane	IDA ISO ISS	9933937
microvillus	IBA IDA ISO ISS	9933937
apical plasma membrane	IDA	9933937

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

lateral plasma membrane

site of polarized growth [inference]

growth cone

cell leading edge

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

cell body [inference]

neuronal cell body

cluster of actin-based cell projections [inference]

brush border

Displaying **all 5** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
actin filament binding	IBA IDA	20089841
calmodulin binding	IEA
cytoskeletal motor activity	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

unconventional myosin-Ia

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 8** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
actin filament organization
cytoskeletal motor activity
nucleotide binding
sensory perception of sound
vesicle transport along actin filament

Displaying **all 6** entries
InterPro
Class I myosin tail homology domain
Class I myosin, motor domain
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 92 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oryctolagus cuniculus	100337769		RABIT14500
Callithrix jacchus	100389198		CALJA44693
Pongo abelii	100433686		PONAB05867
Ailuropoda melanoleuca	100475948		AILME16088
Anolis carolinensis	100555455		ANOCA02543
Loxodonta africana	100659785		LOXAF19588
Cavia porcellus	100727427	10141_0:003cc3	CAVPO05759
Sus scrofa	100739662		PIGXX25650
Cricetulus griseus	100752754	10029_0:0004bc	CRIGR16805
Otolemur garnettii	100945048		OTOGA11517

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements