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Serrate

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43275

PubChem

43275

Alliance of Genome Resources

FB:FBgn0004197

Annotation

Keyword

3D-structure
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0B4LIS1
P18168	Protein beaded

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
cell communication	IEA
Notch signaling pathway	IMP	16093323 16125166 1657403 20203305 23970418 28960177 8756291 9202123
Notch signaling pathway	IGI	35264151 9310337 9553038
Notch signaling pathway	IEA
sensory organ development	IMP	16093323

GO Hierarchy

biological process

immune system process [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

second mitotic wave involved in compound eye morphogenesis

cell communication

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell population proliferation [inference]

glial cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

wing disc pattern formation [inference]

wing disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

cuticle pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

larval salivary gland morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

animal organ development [inference]

sensory organ development

eye development [inference]

compound eye development

imaginal disc development [inference]

eye-antennal disc development

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal process [inference]

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	16643882 1840519
cell surface	IDA	20203305
membrane	IEA
apical plasma membrane	IDA	17006545
axolemma	IDA	1840519

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

apical cortex

cytoplasmic region [inference]

cell cortex region [inference]

apical cortex

cell surface

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
Notch binding	IDA	10504334 12909620 17923477
Notch binding	IBA
Notch binding	IPI	20203305
Notch binding	IEA
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

jagged

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
Notch binding
calcium ion binding
cell communication

Displaying **all 10** entries
InterPro
Delta/Serrate/lag-2 (DSL) protein
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Jagged/Serrate protein
Notch ligand, N-terminal domain
VWFC domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
apical plasma membrane	PMID:17006545
axolemma	PMID:1840519
cell surface	PMID:20203305
plasma membrane	PMID:16643882 PMID:1840519
apical cortex	PMID:15760269

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	182	Xenbase:XB-GENE-485662
Xenopus tropicalis	3714	Xenbase:XB-GENE-485160
Xenopus tropicalis	16449	Xenbase:XB-GENE-485662
Xenopus tropicalis	16450	Xenbase:XB-GENE-485160
Xenopus tropicalis	29146	Xenbase:XB-GENE-485662
Xenopus tropicalis	43275	Xenbase:XB-GENE-485160
Xenopus tropicalis	140421	Xenbase:XB-GENE-485662