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MIRAGE

Rho GTPase activating protein at 100F

Summary

Gene Symbol

RhoGAP100F

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43758

PubChem

43758

Alliance of Genome Resources

FB:FBgn0039883

Annotation

Keyword

Alternative splicing
Cell projection
GTPase activation
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A0B4LJ24
A0A0B4K7S3
A0A0B4K7G3
Q9V9S7	Synapse defective protein 1 homolog
I0C0N0
A0A0B4K6W5
A0A0B4K813

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
signal transduction	IEA
Rho protein signal transduction	ISM
synapse assembly	IDA	20176924
synapse assembly	IMP	20176924
cell migration	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

cortical cytoskeleton organization [inference]

cytoskeletal matrix organization at active zone

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

synapse organization [inference]

synapse assembly

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

presynaptic active zone organization

maintenance of presynaptic active zone structure

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

localization [inference]

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
neuromuscular junction	IDA	20176924
neuromuscular junction	IMP	20176924
cell projection
presynaptic active zone	IDA	20176924 24882013 27526206
synaptic membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

membrane [inference]

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activator activity	ISS
GTPase activator activity	ISM
GTPase activator activity	IBA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho GTPase-activating protein

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
cell migration
regulation of Ras protein signal transduction

Displaying **all 4** entries
InterPro
C2 domain superfamily
C2 domain
Rho GTPase activation protein
Rho GTPase-activating protein domain

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
presynaptic active zone cytoplasmic component	PMID:20176924
neuromuscular junction	PMID:20176924
presynaptic active zone	PMID:20176924 PMID:21715635 PMID:24882013 PMID:27526206
membrane	FB:FBrf0231198

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	43758	Xenbase:XB-GENE-980337
Xenopus tropicalis	84144	Xenbase:XB-GENE-980337
Homo sapiens	85360	HGNC:25824

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025