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interleukin 12B

Summary

Gene Symbol

IL12B

Organism

Ovis aries (sheep)

External Links

NCBI Gene: 443472
PubChem: 443472

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P68220	Cytotoxic lymphocyte maturation factor 40 kDa subunit IL-12 subunit p40

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytokine-mediated signaling pathway	IEA	30032202
positive regulation of mononuclear cell proliferation
immunoglobulin mediated immune response	IEA	30032202
type II interferon production

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type II interferon production

multicellular organismal process [inference]

cytokine production [inference]

type II interferon production

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IEA	30032202
membrane	IEA	22301074
extracellular space
interleukin-12 complex

GO Hierarchy

cellular component

protein-containing complex [inference]

interleukin-12 complex

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
cytokine receptor activity	IEA	22301074 30032202
interleukin-12 alpha subunit binding
protein heterodimerization activity
cytokine activity

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine activity

cytokine binding [inference]

interleukin-12 binding [inference]

interleukin-12 alpha subunit binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-12 subunit beta

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine activity
cytokine-mediated signaling pathway

Displaying **all 6** entries
InterPro
Fibronectin type III superfamily
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-12 beta, central domain
Interleukin-12 beta

Ortholog

Displaying entries **11 - 20** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Papio anubis	100126717	PAPAN31122
Cavia porcellus	100135554	CAVPO09156
Taeniopygia guttata	100217488	TAEGU04558
Meleagris gallopavo	100303696	MELGA04075
Oryctolagus cuniculus	100354852	RABIT09542
Callithrix jacchus	100395403	CALJA25281
Pongo abelii	100435254	PONAB29890
Ailuropoda melanoleuca	100477772	AILME19551
Nomascus leucogenys	100579267	NOMLE25667
Loxodonta africana	100657211	LOXAF20233