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cadherin 5

Summary

Gene Symbol

cdh5

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

445471

PubChem

445471

Alliance of Genome Resources

ZFIN:ZDB-GENE-040816-1

Annotation

Keyword

Angiogenesis
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Glycoprotein
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q68SP4	Vascular endothelial cadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 23** of 23 in total

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GO Term	Evidence Code	PMID
regulation of vasculature development	IGI	29744287
blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment	IMP	23698350
endothelial tube lumen extension involved in blood vessel lumen ensheathment	IMP	23698350

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell adhesion involved in sprouting angiogenesis

cell growth [inference]

unidimensional cell growth

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell-cell junction organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

unidimensional cell growth

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

endothelial tube morphogenesis [inference]

blood vessel lumenization

endothelial tube lumen extension [inference]

endothelial tube lumen extension involved in blood vessel lumen ensheathment

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an endothelium [inference]

endothelial tube morphogenesis [inference]

blood vessel lumenization

endothelial tube lumen extension [inference]

endothelial tube lumen extension involved in blood vessel lumen ensheathment

epithelial tube morphogenesis [inference]

endothelial tube morphogenesis [inference]

blood vessel lumenization

endothelial tube lumen extension [inference]

endothelial tube lumen extension involved in blood vessel lumen ensheathment

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

sprouting angiogenesis

angiogenic sprout fusion

anatomical structure development [inference]

animal organ development [inference]

heart development

system development [inference]

vasculature development

cerebellum vasculature development

growth [inference]

cell growth [inference]

unidimensional cell growth

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

unidimensional cell growth

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

blood vessel endothelial cell delamination [inference]

blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

blood vessel endothelial cell delamination [inference]

blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

blood vessel endothelial cell delamination [inference]

blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

delamination [inference]

blood vessel endothelial cell delamination [inference]

blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
cell-cell junction	IDA	19151727
adherens junction	IBA
bicellular tight junction	IBA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

anchoring junction

cell-cell junction

adherens junction

tight junction [inference]

bicellular tight junction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
beta-catenin binding	IBA
protein phosphatase binding	IBA
cadherin binding	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

beta-catenin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules