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moesin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4478

PubChem

4478

Alliance of Genome Resources

HGNC:7373

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Cell projection
Cytoskeleton
Direct protein sequencing
Disease variant
Host-virus interaction
Phosphoprotein
Reference proteome
S-nitrosylation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HWC0	Membrane-organizing extension spike protein
P26038	Membrane-organizing extension spike protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
immunological synapse formation	IDA	27405666
cytoskeleton organization	IEA
leukocyte cell-cell adhesion	IEP	12082081
regulation of cell shape	IMP	24862762
regulation of cell shape	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

leukocyte migration

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion

leukocyte aggregation [inference]

lymphocyte aggregation [inference]

T cell aggregation

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment of epithelial cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

cell recognition [inference]

cell-cell recognition [inference]

immunological synapse formation

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

membrane docking [inference]

membrane to membrane docking

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

cell motility [inference]

cell migration [inference]

leukocyte migration

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

regulation of cellular component size [inference]

regulation of cell size

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

gland morphogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to lipid [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

response to oxygen-containing compound [inference]

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of vesicle-mediated transport [inference]

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of protein localization to endosome [inference]

regulation of protein localization to early endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of organelle assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of organelle assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of early endosome to late endosome transport

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of protein localization to endosome [inference]

regulation of protein localization to early endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of vesicle-mediated transport [inference]

regulation of early endosome to late endosome transport [inference]

positive regulation of early endosome to late endosome transport

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration

regulation of biological quality [inference]

regulation of cell shape

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size

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GO Term	Evidence Code	PMID
uropod	IEA
extracellular space	HDA	16502470
nucleus	HDA	16791210
cytoplasm	HDA	16791210
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

microvillus membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
double-stranded RNA binding	IDA	21266579
actin binding	IBA
signaling receptor binding	IPI	15819698
structural constituent of cytoskeleton	TAS	1924289
protein binding	IPI	10806479 15020681 16938849 17046996 18586956 20642453 21044950 21148287 22363216 22952686 23241358 23855374 24351927 24695735 24794857 24904275 25009464 26824392 27357661 31046837 32296183 34504087 7844168 9430655

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding

kinase binding [inference]

protein kinase binding

cell adhesion molecule binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Moesin/ezrin/radixin homolog 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin binding
cell adhesion molecule binding
cytoskeletal protein binding
positive regulation of early endosome to late endosome transport
positive regulation of protein localization to early endosome
regulation of organelle assembly

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InterPro
Band 4.1 domain
ERM family, FERM domain C-lobe
Ezrin/radixin/moesin, C-terminal
Ezrin/radixin/moesin, alpha-helical domain
Ezrin/radixin/moesin-like
Ezrin/radixin/moesin
FERM central domain
FERM conserved site
FERM domain
FERM superfamily, second domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112001	immunodeficiency 50	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4478	Xenbase:XB-GENE-1004600
Drosophila melanogaster	5962	FB:FBgn0011661
Drosophila melanogaster	7430	FB:FBgn0011661
Mus musculus	17698	Xenbase:XB-GENE-1004600	MOUSE66497
Rattus norvegicus	81521		RATNO44516
Danio rerio	286739		DANRE36265
Ciona intestinalis	445597		CIOIN03638
Canis lupus familiaris	491924		CANLF19841
Sus scrofa	494458		PIGXX37440
Bos taurus	540426		BOVIN37163

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements